Kindlin-3 in the immune system.

نویسندگان

  • Susanna C Fagerholm
  • Hwee San Lek
  • Vicky L Morrison
چکیده

Kindlin-3 is a member of the kindlin family of focal adhesion proteins which bind to integrin beta-chain cytoplasmic domains to regulate integrin function. In contrast to kindlin-1 and kindlin-2 proteins, kindlin-3 is expressed mainly in the hematopoietic system. Mutations in kindlin-3 result in the rare genetic disorder, leukocyte adhesion deficiency type III (LAD-III), which is characterized by bleeding and recurrent infections due to deficient beta1, beta2 and beta3 integrin activation in platelets and leukocytes. Here, we review the role of kindlin-3 in integrin activation and in different immune cell functions.

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عنوان ژورنال:
  • American journal of clinical and experimental immunology

دوره 3 1  شماره 

صفحات  -

تاریخ انتشار 2014